Preparation Method of Nano/Macroporous Bone Tissue Scaffolds for Regenerative Medicine (Technology #: 051306-01)


The present invention provides a method, based on sol-gel processing and polymerization-induced phase separation, for preparing a silica-based bioactive scaffold, in which the pore structure, consisting of interconnected pores of both hundreds of micrometers, and several to tens of nanometers in size, is optimized for enhanced bone regeneration performance. (See figures below) The sol-gel process is a low-cost and versatile method for preparing scaffolds and the phase separation which is induced to occur in the proposed technique results in an interconnected, coral-like, morphology, which leads to structurally stronger materials than the ones achieved by other methods.

This technology involves the harvesting and culture of stem cells from the patient on the scaffold in vitro, thereby creating a tissue/scaffold bio-composite which is then implanted in the damaged site, with tissue regeneration occurring at the rate at which the scaffold reabsorbs. Additionally,

  • The macropores in excess of 100 mm are required for bone cell in-growth and proliferation and vascularisation Regeneration of diseased or damaged tissue to its original state or function
  • The low-cost and versatile sol-gel process allows the control of composition (e.g. Ca/P molar ratio), texture (pore size and shape), homogeneous oxide materials, and scaffold shape control


A patent cooperation treaty (PCT) application, Canadian national phase patent application, European national phase patent application, and US national phase patent application have all been filed.

Himanshu Jain's Lehigh Page

Marketing Abstract
Patent Information:
Life Sciences
For Information, Contact:
Yatin Karpe
Associate Director
Lehigh University
Himanshu Jain
Ana Marques
Rui Almeida
Biomedical Applications
Bone Regeneration
Medical Treatment
Regenerative Medicine
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